The Chemical Synthesis of Proteins
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Presents the synthesis of the ribonuclease A enzyme by Dr. R. B. Merrifield's solid-phase method of peptide synthesis, showing formulas involved and demonstrating equipment needed. Uses a three-dimensional model, schema, and laboratory demonstration to illustrate protein and enzyme structure and the problems of synthesizing them. Discusses schematically in formulas the automated solid-phase method of peptide synthesis, observing the chemical reactions involved, and records the materials, electro-mechanical hardware, and program needed for the process. Compares the synthetic results with natural enzymatic activity.
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