"Spontaneous" Gene Mutation
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Discusses the characteristics of gene mutations and the importance of such mutations in evolution. Notes in particular the detrimental nature of most mutations and their incomplete recessivity. Shows how changes in gene dosage give information on how mutants act to produce phenotypes. Presents the per cell and per locus spontaneous mutations rates for gametes of Drosophila, mice, and men. Enumerates the factors affecting spontaneous mutation rate including aging effects, natural selection, mutator genes, temperature, and detrimental conditions in general. Lecture given by Dr. H. J. Muller.
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