Selection, Genetic Death and Genetic Radiation Damage
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Portrays the frequency of a mutant in the gene pool as reaching a state of equilibrium when, per generation, its origination by mutation equals its elimination by genetic death. Discusses genetic death and presents examples of how genetic loads are changed subsequent to radiation exposure. Pictures the great majority of mutants as harmful when homozygous, but some cases, as in sickle call anemia, heterozygotes are adaptively superior to normal homozygotes. Explains balanced polymorphism, by which a gene is retained in the population despite its lethality when homozygous because of the advantage it confers when heterozygous. Lectures given by Dr. Thomas Dobzhansky.
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