Dr. Jekyll and Sister Hyde

Dr. Henry Jekyll dedicates his life to curing all known illnesses. However his lecherous friend, Professor Robertson, remarks that his experiments take so long to actually be discovered, he will no doubt be dead by the time he is able to achieve anything. Dr. Hyde transforms into Mrs. Edwina Hyde after mixing female hormones into a serum and drinking it has the effect of changing his character (for the worse) and changing his gender, transforming him into a beautiful but evil woman.